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HRID267621

反应详情

EQUATION

反应方程式

HRID 267621 的结构方程式

REACTANTS

反应物

2
结构：Br
HCID260

Hydrogen Bromide

BrH

结构：C[C@]12C[C@H]3O[C@H]3C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C#N)[C@@]3(C)CC(=O)[C@@H]12
HCID86733137

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12C[C@H](Br)[C@@H](O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C#N)[C@@]3(C)CC(=O)[C@@H]12
HCID86733136

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Aqueous 48% hydrobromic acid (60 ml.) was added to a solution of 17β-cyano-2α,3α-epoxy-5α-androstan-11-one (3.03g.) in chloroform (175ml.) and the mixture stirred at room temperature for 1 hr. The organic phase was separated, washed with aqueous 10% sodium bicarbonate and water and dried. Filtration and evaporation followed by preparative t.l.c. afforded the pure title compound as a white froth (2.16g.); [α]D + 68.5°, (c 0.6).

WORKUP

后处理

  1. customThe organic phase was separated
  2. washwashed with aqueous 10% sodium bicarbonate and water
  3. customdried
  4. filtrationFiltration and evaporation