反应详情

温度

-10 °C

From an aqueous solution of 2.8 parts of N-(2,6-dimethylphenyl)-N-(1-propyl-4-piperidinyl)-2-thiopheneacetamide dihydrochloride, the free base is liberated by alkalization with sodium hydrogen carbonate solution. The free base is extracted with 1,1'-oxybisethane. The extract is dried and evaporated. The oily residue is dissolved in 56 parts of hexane and after cooling to -10° C., the solid free base is precipitated. It is filtered off and dried, yielding 1.6 parts of N-(2,6-dimethylphenyl)-N-(1-propyl-4-piperidinyl)-2-thiopheneacetamide; mp. 62.5° C.

1. extractionThe free base is extracted with 1,1'-oxybisethane
2. customThe extract is dried
3. customevaporated
4. dissolutionThe oily residue is dissolved in 56 parts of hexane
5. customthe solid free base is precipitated
6. filtrationIt is filtered off
7. customdried