HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178512778, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Methyl-2-thiopseudourea sulfate | HCID 75270 | — |
| Reactant | 3-(aminomethyl)-3,4-dihydro-2H-1,5-benzodioxepin-3-ol | HCID 15557297 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178512778 | HCID 178512778 | — |
Reaction Steps
3-hydroxy-3-aminomethyl-3,4-dihydro-2H-1,5-benzodioxepin from Example 1, Step E, (1.95 g., 10 millimoles) and 2.78 g. (10 millimoles) of S-methylisothiourea sulfate in 15 mls. of dimethylformamide and 2 mls. of water is heated at 90°-100° C. for 5 hours. The solvent is evaporated in vacuo and the residue recrystallized from ethanol to give 3-hydroxy-3-guanidinomethyl-3,4-dihydro-2H-1,5-benzodioxepin sulfate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03944560 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-c8e57c340db2440893cde78b55745a92 |
| Source note | uspto-grants-1976_03 |