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HRID267768

反应详情

EQUATION

反应方程式

HRID 267768 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CSC(=N)N.O=S(=O)(O)O
HCID75270

Sulfuric acid--methyl carbamimidothioate (1/1)

C2H8N2O4S2

结构：NCC1(O)COc2ccccc2OC1
HCID15557297

3-(Aminomethyl)-3,4-dihydro-2H-1,5-benzodioxepin-3-ol

C10H13NO3

PRODUCTS

生成物

1
结构：N=C(N)NCC1(O)COc2ccccc2OC1.O=S(=O)(O)O
HCID178512778

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

3-hydroxy-3-aminomethyl-3,4-dihydro-2H-1,5-benzodioxepin from Example 1, Step E, (1.95 g., 10 millimoles) and 2.78 g. (10 millimoles) of S-methylisothiourea sulfate in 15 mls. of dimethylformamide and 2 mls. of water is heated at 90°-100° C. for 5 hours. The solvent is evaporated in vacuo and the residue recrystallized from ethanol to give 3-hydroxy-3-guanidinomethyl-3,4-dihydro-2H-1,5-benzodioxepin sulfate.

WORKUP

后处理

  1. customThe solvent is evaporated in vacuo
  2. customthe residue recrystallized from ethanol