Hydrochloric Acid → HCID 21553917, compound

HRID 267777Notes

Reaction equation

HRID 267777 reaction equation
C([O:4][C:5]1([CH2:22][N:23]([CH:27]([CH3:29])[CH3:28])C(=O)C)[CH2:11][O:10][C:9]2[CH:12]=[CH:13][C:14]([NH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:15][C:8]=2[O:7][CH2:6]1)(=O)C.Cl.C(O)C.[OH-].[Na+]>O>[OH:4][C:5]1([CH2:22][NH:23][CH:27]([CH3:28])[CH3:29])[CH2:11][O:10][C:9]2[CH:12]=[CH:13][C:14]([NH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:15][C:8]=2[O:7][CH2:6]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 538213713-acetoxy-3-(N-acetylisopropylaminomethyl)-7-carbethoxyamino-3,4-dihydro-2H-1,5-benzodioxepin

Product 1

HCID 21553917HCID 21553917, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-Acetoxy-3-(N-acetylisopropylaminomethyl)-7-carbethoxyamino-3,4-dihydro-2H-1,5-benzodioxepin (4.1 g., 10 millimoles) is warmed five hours at 40°C. with 6 ml. of concentrated hydrochloric acid and 34 ml. of ethanol. The solution is cooled, taken to the basic side with sodium hydroxide, diluted with water, and extracted with diethyl ether to give 3-hydroxy-3-isopropylaminomethyl-7-carbethoxyamino-3,4-dihydro-2H-1,5-benzodioxepin.

Workup

  1. temperatureThe solution is cooled
  2. extractionextracted with diethyl ether

Sources & evidence

ORD record
ord-44bce3965b8f4f6baac9fdac01e781a7
Source dataset
uspto-grants-1976_03
Patent number
US03944560

Reaction notes

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