反应详情

A mixture of 45.7 g. (0.3 moles) of 4'-fluoropropiophenone, 9 g. (0.3 moles) of paraformaldehyde, 4 g. (0.03 mole) of anhydrous potassium carbonate and 200 ml. of methyl alcohol is stirred at 35°C for two days. The reaction is quenched in water and acidified with hydrochloric acid. The product is extracted into benzene. The benzene layer is washed with water and concentrated in vacuo to give 4'-fluoro-3-hydroxy-2-methylpropiophenone.

1. additionA mixture of 45.7 g
2. customThe reaction is quenched in water
3. extractionThe product is extracted into benzene
4. washThe benzene layer is washed with water
5. concentrationconcentrated in vacuo