Formaldehyde → 1-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one

HRID 267821ノート

反応式

HRID 267821 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[CH2:12]=[O:13].C(=O)([O-])[O-].[K+].[K+]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:11])[CH:9]([CH3:10])[CH2:12][OH:13])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 712FormaldehydeHCID 11430Potassium CarbonateHCID 680044-Fluoropropiophenone

生成物 1

HCID 215218911-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 45.7 g. (0.3 moles) of 4'-fluoropropiophenone, 9 g. (0.3 moles) of paraformaldehyde, 4 g. (0.03 mole) of anhydrous potassium carbonate and 200 ml. of methyl alcohol is stirred at 35°C for two days. The reaction is quenched in water and acidified with hydrochloric acid. The product is extracted into benzene. The benzene layer is washed with water and concentrated in vacuo to give 4'-fluoro-3-hydroxy-2-methylpropiophenone.

後処理

  1. additionA mixture of 45.7 g
  2. customThe reaction is quenched in water
  3. extractionThe product is extracted into benzene
  4. washThe benzene layer is washed with water
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-52bed7bfa0fa4f3c9ff0a8177caa4dfc
出典データセット
uspto-grants-1976_03
特許番号
US03944600

反応ノート

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