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O-Xylene → 5-Fluoro-2-methylindan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Xylene | HCID 7237 | — |
| 反応物 | Phosphorus oxide (P4O10) | HCID 14812 | — |
| 反応物 | 1-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one | HCID 21521891 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Fluoro-2-methylindan-1-one | HCID 3016257 | — |
反応手順
A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for one hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03944600 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-e35a1b1b9bd74744aba18c195be0050a |
| 出典メモ | uspto-grants-1976_03 |