2,4,6-Trimethylpyridine → HCID 21404983, compound

HRID 267873Notes

Reaction equation

HRID 267873 reaction equation
[I-].[Li+].CC1C=C(C)N=C(C)C=1.C[O:13][C:14]1[CH:15]=[C:16]([CH2:22][CH2:23][NH:24][C:25](=[O:30])[C:26]([CH3:29])([CH3:28])[CH3:27])[CH:17]=[CH:18][C:19]=1[O:20]C>>[OH:13][C:14]1[CH:15]=[C:16]([CH2:22][CH2:23][NH:24][C:25](=[O:30])[C:26]([CH3:28])([CH3:27])[CH3:29])[CH:17]=[CH:18][C:19]=1[OH:20]

Participants

4

Reactant 3

HCID 79532,4,6-TrimethylpyridineHCID 66321Lithium iodideHCID 795486N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2-dimethylpropanamide

Product 1

HCID 21404983HCID 21404983, compound

Procedure

Suspend 0.86 g. of lithium iodide in 10.0 ml. of S-collidine and add 0.53 g. of N-[β-(3,4-dimethoxyphenyl)-ethyl] 2,2-dimethylpropionamide (see Example 5, step A). Reflux the mixture for 3 hours with vigorous stirring, then cool to room temperature. Extract the two liquid phases with ethyl acetate and water and proceed as described in Example 8 to obtain the product of this example.

Workup

  1. temperatureReflux the mixture for 3 hours with vigorous stirring
  2. extractionExtract the two liquid phases with ethyl acetate and water
  3. customto obtain the product of this example

Sources & evidence

ORD record
ord-ad634ec467064b259827127fd55059a1
Source dataset
uspto-grants-1976_03
Patent number
US03944675

Reaction notes

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