HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-YL)-2-pyrrolin-2-YL]phenothiazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-Methyl-2-pyrrolidone | HCID 66055 | — |
| Reactant | Methyl phenothiazin-2-yl ether | HCID 74490 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2-Methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-YL)-2-pyrrolin-2-YL]phenothiazine hydrochloride | HCID 20307135 | 8.6% |
Reaction Steps
Reaction of 5-methyl-2-pyrrolidinone, 2-methoxyphenothiazine and phosphorus oxychloride in 1,2-dichloroethane according to the procedure of Example 4 affords 2-METHOXY-10-[5-METHYL-1-(5-METHYL-1-PYRROLIN-2-YL)-2-PYRROLIN-2-YL]PHENOTHIAZINE HYDROCHLORIDE (8.6% yield), m.p. 236.5°-238.5° C. (corr.), from ethanol-ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946004 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-e2b9cc5433e04e85a624d578ad21690a |
| Source note | uspto-grants-1976_03 |