2,3-Dichloropyrazine → 2-Chloro-3-phenoxypyrazine

HRID 267933Notes

Reaction equation

HRID 267933 reaction equation
[O-:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+].[Cl:9][C:10]1[C:15](Cl)=[N:14][CH:13]=[CH:12][N:11]=1>>[Cl:9][C:10]1[C:15]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:14][CH:13]=[CH:12][N:11]=1

Participants

3

Reactant 2

HCID 785752,3-DichloropyrazineHCID 4445035Phenolate Sodium

Product 1

HCID 205289612-Chloro-3-phenoxypyrazine

Procedure

A suspension of 0.1 mole of sodium phenoxide and 0.1 mole 2,3-dichloropyrazine is refluxed 10-20 hours. The cooled mixture is extracted with diethyl ether, washed with cold 2N sodium hydroxide solution, dried, and evaporated to give 2-chloro-3-phenoxypyrazine.

Workup

  1. temperatureis refluxed 10-20 hours
  2. extractionThe cooled mixture is extracted with diethyl ether
  3. washwashed with cold 2N sodium hydroxide solution
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-be942f0565a844a5afad22dc7374412a
Source dataset
uspto-grants-1976_03
Patent number
US03946009

Reaction notes

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