Phosphorus oxychloride → 3-Chloro-2,5-dimethylpyrazine

HRID 267935Notes

Reaction equation

HRID 267935 reaction equation
O[C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[C:4]([CH3:9])[N:3]=1.P(Cl)(Cl)([Cl:12])=O>>[Cl:12][C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[C:4]([CH3:9])[N:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178430529HCID 178430529, compound

Product 1

HCID 667713-Chloro-2,5-dimethylpyrazine

Procedure

The 2-hydroxy-3,6-dimethylpyrazine disclosed by Baxter et al can be reacted with phosphorus oxychloride by the method described in Preparation 13, Step B, to provide 2-chloro-3,6-dimethylpyrazine.

Workup

  1. customdescribed in Preparation 13, Step B

Sources & evidence

ORD record
ord-7789684496774906bbbb675bbec3f851
Source dataset
uspto-grants-1976_03
Patent number
US03946009

Reaction notes

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