Ammonium Hydroxide → 2-Amino-6-methoxypyrazine 4-oxide

HRID 267940Notes

Reaction equation

HRID 267940 reaction equation
Cl[C:2]1[CH:7]=[N+:6]([O-:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1.[OH-].[NH4+:12]>>[NH2:12][C:2]1[CH:7]=[N+:6]([O-:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 205289402-Chloro-6-methoxypyrazine 4-oxide

Product 1

HCID 205289822-Amino-6-methoxypyrazine 4-oxide

Procedure

2-Chloro-6-methoxypyrazine 4-oxide is treated with an excess of ammonium hydroxide in an autoclave at 150° C. for 14 hours. The reaction mixture is cooled and evaporated to dryness to give the crude product which may be used in the next step as is.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-033040546c5a4252b7eedeb9cec33dd5
Source dataset
uspto-grants-1976_03
Patent number
US03946009

Reaction notes

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