Phosphorus oxychloride → 2-Chloro-3,5-dimethoxypyrazine

HRID 267950Notes

Reaction equation

O[C:2]1[C:7]([O:8][CH3:9])=[N:6][C:5]([O:10][CH3:11])=[CH:4][N:3]=1.P(Cl)(Cl)([Cl:14])=O>>[Cl:14][C:2]1[C:7]([O:8][CH3:9])=[N:6][C:5]([O:10][CH3:11])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178493795HCID 178493795, compound

Product 1

HCID 205289862-Chloro-3,5-dimethoxypyrazine

Procedure

Treatment of the above-obtained 2-hydroxy-3,5-dimethoxypyrazine with phosphorus oxychloride by the method described in Preparation 13, Step B, gives 2-chloro-3,5-dimethoxypyrazine.

Sources & evidence

ORD record: ord-e8c10d064b574d4fb30044247251f805
Source dataset: uspto-grants-1976_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03946009

Reaction notes

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