HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1,2,3,4-Tetrahydro-8,9-dimethoxy-3-(2-morpholinoethyl)5H-[1]benzopyrano-[3,4-c]pyridin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | 8,9-dimethoxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one | HCID 10825289 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,2,3,4-Tetrahydro-8,9-dimethoxy-3-(2-morpholinoethyl)5H-[1]benzopyrano-[3,4-c]pyridin-5-one | HCID 21447171 | — |
Reaction Steps
A mixture of 7.85 g (0.03 m) of 1,2,3,4-tetrahydro-8,9-dimethoxy-5H-[1]benzopyrano [3,4-c]pyridin-5-one, 6.15 g (0.033 m) of N-(2-chloroethyl) morpholine HCl and 7.08 g (0.07 m) of triethylamine in 250 cc of ethanol was refluxed for 6 hr. and filtered hot. Treatment of the hot reaction solution with excess HCl 6 hr. and cooling to room temperature afforded crude product. Crystallization from 75% EtOH afforded analytical material mp. 238°-40° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946008 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-4ca38ae1afb444898b68604a3510b845 |
| Source note | uspto-grants-1976_03 |