反应详情

A mixture of 7.85 g (0.03 m) of 1,2,3,4-tetrahydro-8,9-dimethoxy-5H-[1]benzopyrano [3,4-c]pyridin-5-one, 6.15 g (0.033 m) of N-(2-chloroethyl) morpholine HCl and 7.08 g (0.07 m) of triethylamine in 250 cc of ethanol was refluxed for 6 hr. and filtered hot. Treatment of the hot reaction solution with excess HCl 6 hr. and cooling to room temperature afforded crude product. Crystallization from 75% EtOH afforded analytical material mp. 238°-40° C.

1. temperaturewas refluxed for 6 hr
2. filtrationand filtered hot
3. customwith excess HCl 6 hr
4. customafforded crude product
5. customCrystallization from 75% EtOH afforded analytical material mp. 238°-40° C.