Potassium Iodide → HCID 21552992, compound

HRID 267977Notes

Reaction equation

HRID 267977 reaction equation
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[OH:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1)=[O:28].C(=O)(O)[O-].[K+].[I-].[K+]>C1(C)C=CC=CC=1.O>[ClH:21].[OH:8][C:7]([CH:9]1[CH2:14][CH2:13][N:12]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=2)=[O:28])[CH2:11][CH2:10]1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 15723AzacyclonolHCID 516893Potassium BicarbonateHCID 185181716-Chloro-1-(4-methoxyphenyl)hexan-1-one

Product 1

HCID 21552992HCID 21552992, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1140TolueneSolvent

Procedure

A mixture of 27.6 g (0.1 mole) of α,α-diphenyl-4-piperidinemethanol, 26.5 g (0.11 mole) of 6-chloro-4'-methoxycaprophenone, 20 g of potassium bicarbonate, and 0.1 g of potassium iodide in 300 ml of toluene and 45 ml of water is stirred on a steam bath for about 82 hours then worked up by the procedure described in Example 5 to give 6-[4-(α-hydroxy-α-phenylbenzyl)piperidino]-4'-methoxycaprophenone hydrochloride.

Sources & evidence

ORD record
ord-26d5cc26aa504769ba2730d44214da3f
Source dataset
uspto-grants-1976_03
Patent number
US03946022

Reaction notes

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