Diethyl oxalacetate → HCID 68133663, compound

HRID 268017Notes

Reaction equation

HRID 268017 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=O.[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=O)[CH3:13].[CH2:25]([O:27][C:28](=[O:33])/[CH:29]=[C:30](\[NH2:32])/[CH3:31])[CH3:26]>C(O)C>[CH2:25]([O:27][C:28]([C:29]1[CH:5]([C:4]2[CH:7]=[CH:8][C:9]([O:10][CH3:11])=[C:2]([F:1])[CH:3]=2)[C:16]([C:15]([O:14][CH2:12][CH3:13])=[O:24])=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[NH:32][C:30]=1[CH3:31])=[O:33])[CH3:26]

Participants

5

Reactant 3

HCID 66951Diethyl oxalacetateHCID 676963-Fluoro-p-anisaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-

Product 1

HCID 68133663HCID 68133663, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

After heating a solution of 17 g of 3-fluoro-4-methoxybenzaldehyde, 20.9 g of oxalacetic acid diethyl ester and 14.3 g of β-aminocrotonic acid ethyl ester in 80 ccs of ethanol under reflux, the mixture is evaporated in vacuo and the reaction product is obtained as a light yellow oil.

Workup

  1. temperatureunder reflux
  2. customthe mixture is evaporated in vacuo
  3. customthe reaction product is obtained as a light yellow oil

Sources & evidence

ORD record
ord-b40eae7f4504422f975f579b862ab314
Source dataset
uspto-grants-1976_03
Patent number
US03946028

Reaction notes

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