m-Chloroperbenzoic acid → HCID 21452387, compound

HRID 268026Notes

Reaction equation

HRID 268026 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:9][C:10]1[NH:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)=[S:8].ClC1C=CC=C(C(OO)=O)C=1>C(Cl)(Cl)Cl>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]1[S:8][N:11]2[C:10](=[N:14][C:13]3[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=32)[N:9]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 54072285HCID 54072285, compound

Product 1

HCID 21452387HCID 21452387, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 0.51 g. of 2-(2-pyrazinylthiocarbonylamino)-benzimidazole [(IV), R = 2-pyrazinyl] in 200 ml. of chloroform at 20°-30°C. (room temperature) is added 0.5 g. of m-chloroperbenzoic acid. The reaction mixture is allowed to stand for 15 hours (overnight) and washed with 20 ml. of potassium bicarbonate solution, 20 ml. of water and dried over magnesium sulphate. The chloroform is evaporated and the residue is recrystallized from methanol-chloroform to yield 2-(2-pyrazinyl)-1,2,4-thiadiazolo-[2,3-a]-benzimidazole [(I), R = 2-pyrazinyl].

Workup

  1. wash(overnight) and washed with 20 ml
  2. dry with materialof water and dried over magnesium sulphate
  3. customThe chloroform is evaporated
  4. customthe residue is recrystallized from methanol-chloroform

Sources & evidence

ORD record
ord-f29de8146bb8486c8ea6b9d8e0c251f3
Source dataset
uspto-grants-1976_03
Patent number
US03946031

Reaction notes

Loading…