Hydrochloric Acid → HCID 68131207, compound

Participants

Reaction Steps

73.7 g of 2,3-dimethoxy-6-(2-methoxy-3,4-methylenedioxy-6-benzylmethylaminoethylphenylacetyl)benzoic acid ethyl ester as the HCl salt (mp 160°-161°C) was dissolved in 1.8 l. of ethanol. The resulting mixture was hydrogenated in the presence of 11.5 g of 10% Pd/C at 3 atm for 20 hr. After removal of the catalyst, the solution was concentrated to a small volume. After cooling, 2,3-dimethoxy-6-(2-methoxy-3,4-methylenedioxy-6-methylaminoethylphenylacetyl)benzoic acid ethyl ester hydrochloride of mp 199°-200° was isolated.

Provenance & Evidence