Hydrochloric Acid → HCID 68131207, compound

HRID 268058Notes

Reaction equation

HRID 268058 reaction equation
[CH2:1]([O:3][C:4](=[O:40])[C:5]1[C:10]([C:11](=[O:35])[CH2:12][C:13]2[C:18]([CH2:19][CH2:20][NH:21][CH2:22]CC3C=CC=CC=3)=[CH:17][C:16]3[O:30][CH2:31][O:32][C:15]=3[C:14]=2[O:33][CH3:34])=[CH:9][CH:8]=[C:7]([O:36][CH3:37])[C:6]=1[O:38][CH3:39])[CH3:2].[ClH:41]>[Pd].C(O)C>[ClH:41].[CH2:1]([O:3][C:4](=[O:40])[C:5]1[C:10]([C:11](=[O:35])[CH2:12][C:13]2[C:18]([CH2:19][CH2:20][NH:21][CH3:22])=[CH:17][C:16]3[O:30][CH2:31][O:32][C:15]=3[C:14]=2[O:33][CH3:34])=[CH:9][CH:8]=[C:7]([O:36][CH3:37])[C:6]=1[O:38][CH3:39])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68130752HCID 68130752, compound

Product 1

HCID 68131207HCID 68131207, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

73.7 g of 2,3-dimethoxy-6-(2-methoxy-3,4-methylenedioxy-6-benzylmethylaminoethylphenylacetyl)benzoic acid ethyl ester as the HCl salt (mp 160°-161°C) was dissolved in 1.8 l. of ethanol. The resulting mixture was hydrogenated in the presence of 11.5 g of 10% Pd/C at 3 atm for 20 hr. After removal of the catalyst, the solution was concentrated to a small volume. After cooling, 2,3-dimethoxy-6-(2-methoxy-3,4-methylenedioxy-6-methylaminoethylphenylacetyl)benzoic acid ethyl ester hydrochloride of mp 199°-200° was isolated.

Workup

  1. customAfter removal of the catalyst
  2. concentrationthe solution was concentrated to a small volume
  3. temperatureAfter cooling

Sources & evidence

ORD record
ord-7ebdca336f014372b983ef4c3b544bec
Source dataset
uspto-grants-1976_03
Patent number
US03946041

Reaction notes

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