反应详情

To a suitable reaction vessel equipped with a thermometer, agitator and venting means are charged approximately 500 parts by weight of isopropyl alcohol and approximately 53 parts by weight of thiolactic acid (about 1/2 mole). To the so-charged mass is added about 1 part by weight of concentrated H2SO4. The contents of the so-charged vessel are heated with agitation under a nitrogen atmosphere to reflux temperature and maintained at that temperature for about 4 hours. The contents are cooled to about room temperature. Excess alcohol is stripped off by distillation under vacuum. The liquid product may be vacuum distilled if a high purity product is desired. Isopropyl-alpha-mercapto-propionate is obtained.

1. customTo a suitable reaction vessel equipped with a thermometer, agitator and venting means
2. temperatureThe contents of the so-charged vessel are heated with agitation under a nitrogen atmosphere
3. temperatureto reflux temperature
4. temperaturemaintained at that temperature for about 4 hours
5. temperatureThe contents are cooled to about room temperature
6. distillationExcess alcohol is stripped off by distillation under vacuum
7. distillationdistilled if a high purity product