Trifluoroacetic acid → HCID 178477382, compound

HRID 268133Notes

Reaction equation

HRID 268133 reaction equation
FC(F)(F)C(O)=O.C(OC([NH:15][CH2:16][C:17]1[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=1[CH2:23][C:24]([NH:26][CH:27]1[C:45](=[O:46])[N:29]2[C:30]([C:42]([OH:44])=[O:43])=[C:31]([CH:34]([S:36][C:37]3[NH:41][N:40]=[N:39][N:38]=3)[CH3:35])[CH2:32][S:33][C@H:28]12)=[O:25])=O)(C)(C)C>CCOCC>[NH2:15][CH2:16][C:17]1[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=1[CH2:23][C:24]([NH:26][CH:27]1[C:45](=[O:46])[N:29]2[C:30]([C:42]([OH:44])=[O:43])=[C:31]([CH:34]([S:36][C:37]3[NH:38][N:39]=[N:40][N:41]=3)[CH3:35])[CH2:32][S:33][C@H:28]12)=[O:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178477383HCID 178477383, compound

Product 1

HCID 178477382HCID 178477382, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of trifluoroacetic acid (2 ml.) and 5c (1.30 g., 2.4 mmoles) was stirred magnetically for 30 min. at room temperature. The mixture was diluted with ether (50 ml.) to precipitate the trifluoroacetate of 6c. The trifluoroacetate was suspended in a small amount of water (2 ml.) and the suspension was adjusted at pH 6 with ammonium hydroxide and diluted with acetonitrile (200 ml.) to give 6c which was washed with acetonitrile (50 ml.) and dried.

Workup

  1. customto precipitate the trifluoroacetate of 6c
  2. additiondiluted with acetonitrile (200 ml.)

Sources & evidence

ORD record
ord-104d1cf9700c418ab4cfa5d98735583a
Source dataset
uspto-grants-1976_03
Patent number
US03946000

Reaction notes

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