Trifluoroacetic acid → HCID 68130533, compound

HRID 268134Notes

Reaction equation

HRID 268134 reaction equation
FC(F)(F)C(O)=O.C(OC([NH:15][CH2:16][C:17]1[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=1[CH2:23][C:24]([NH:26][CH:27]1[C:45](=[O:46])[N:29]2[C:30]([C:42]([OH:44])=[O:43])=[C:31]([CH2:34][S:35][C:36]3[S:37][C:38]([CH3:41])=[N:39][N:40]=3)[CH2:32][S:33][C@H:28]12)=[O:25])=O)(C)(C)C>CCOCC>[NH2:15][CH2:16][C:17]1[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=1[CH2:23][C:24]([NH:26][CH:27]1[C:45](=[O:46])[N:29]2[C:30]([C:42]([OH:44])=[O:43])=[C:31]([CH2:34][S:35][C:36]3[S:37][C:38]([CH3:41])=[N:39][N:40]=3)[CH2:32][S:33][C@H:28]12)=[O:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68132162HCID 68132162, compound

Product 1

HCID 68130533HCID 68130533, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of trifluoroacetic acid (2 ml.) and 5d (1.20 g., 2 mmoles) was stirred for 30 min at room temperature and diluted with ether (50 ml.) to precipitate the trifluoroacetate of 6d. The trifluoroacetate was slurried in water (2 ml.), adjusted at pH 6 with ammonium hydroxide and diluted with acetonitrile (200 ml.) to precipitate 6d. Yield 0.75 g. (76%). M.p. 215° - 220° C. (dec.).

Workup

  1. customto precipitate the trifluoroacetate of 6d
  2. additiondiluted with acetonitrile (200 ml.)
  3. customto precipitate 6d

Sources & evidence

ORD record
ord-affc3d75bfd447ddb1a19c9aca8f6b82
Source dataset
uspto-grants-1976_03
Patent number
US03946000

Reaction notes

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