Methanol → HCID 54525598, compound

HRID 268167Notes

Reaction equation

HRID 268167 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([CH3:12])[C:10](=[O:13])[CH:9]3[CH2:14][CH2:15][CH2:16][N:8]3[C:7](=O)[C:6]=2[CH:18]=1.B.CO>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([CH3:12])[C:10](=[O:13])[CH:9]3[CH2:14][CH2:15][CH2:16][N:8]3[CH2:7][C:6]=2[CH:18]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 6331BoraneHCID 21030685HCID 21030685, compound

Product 1

HCID 54525598HCID 54525598, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The above compound is obtained when (+)-7 -chloro-1,2,3,11a-tetrahydro-10-methyl-5 H-pyrrolo[2,1-c] [1,4] -benzodiazepin-5,11(10H)-dione (melting point 155°-157°C. is prepared from L-proline and 5-chloro-N-methylisatoic acid as described in Example 1) is treated with 1M borane in tetrahydrofuran as described in Example 1. The hydrochloride salt melts at 270°-272°C., [α]D 25 + 377° (1.03%) methanol).

Sources & evidence

ORD record
ord-c5ac487070844b24b3fdb4da7ee72b74
Source dataset
uspto-grants-1976_03
Patent number
US03947408

Reaction notes

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