Borane → HCID 54307883, compound

HRID 268168Notes

Reaction equation

HRID 268168 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([CH3:12])[C:10](=[O:13])[CH:9]3[CH2:14][CH2:15][CH2:16][N:8]3[C:7](=O)[C:6]=2[CH:18]=1.B>O1CCCC1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([CH3:12])[C:10](=[O:13])[CH:9]3[CH2:14][CH2:15][CH2:16][N:8]3[CH2:7][C:6]=2[CH:18]=1

Participants

4

Reactant 2

HCID 6331BoraneHCID 68144319HCID 68144319, compound

Product 1

HCID 54307883HCID 54307883, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

When (+)-7,10-dimethyl-1,2,3,11a-tetrahydro-5 H-pyrrolo[2,1-c] [1,4] benzodiazepin-5,11(10H)-dione (melting point 137°-139°C., prepared from L-proline and N,5-dimethylisatoic anhydride as described in Example 1) is treated with 1M borane in tetrahydrofuran as described in Example 1, the above compound, melting point 80°-82° is obtained. The hydrochloride salt melts at 213°-215°C.

Workup

  1. customthe above compound, melting point 80°-82° is obtained

Sources & evidence

ORD record
ord-9344264846a54d45a7cafe7b86fccc05
Source dataset
uspto-grants-1976_03
Patent number
US03947408

Reaction notes

Loading…