反应详情

(i)(a) A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in acetic acid (200 ml.) was heated under reflux for 10 hours. Following cooling to 15°-20°, the solid which crystallised was collected and washed with isopropyl alcohol to give 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (45.5 g.), m.p. 189°-192°.

1. temperatureunder reflux for 10 hours
2. temperatureFollowing cooling to 15°-20°
3. customthe solid which crystallised
4. customwas collected
5. washwashed with isopropyl alcohol