HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cysteamine Hydrochloride → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cysteamine Hydrochloride | HCID 9082 | — |
| Reactant | 4-Methylimidazol-5-ylmethanolhydrochloride | HCID 3084707 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride | HCID 3015999 | 184.6% |
Reaction Steps
(i)(a) A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in acetic acid (200 ml.) was heated under reflux for 10 hours. Following cooling to 15°-20°, the solid which crystallised was collected and washed with isopropyl alcohol to give 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (45.5 g.), m.p. 189°-192°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04151288 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-6ef02c204531486b9758f3aef7927054 |
| Source note | uspto-grants-1979_04 |