Borane → HCID 12203805, compound

HRID 268175Notes

Reaction equation

HRID 268175 reaction equation
[NH:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([OH:5])=O.[C:9]12[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=1)[NH:14]C(=O)O[C:10]2=O.B>O1CCCC1>[CH2:6]1[CH:2]2[C:3](=[O:5])[NH:14][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:9]=3[CH2:10][N:1]2[CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 6331BoraneHCID 8359Isatoic AnhydrideHCID 145742L-Proline

Product 1

HCID 12203805HCID 12203805, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The above compound, melting point 174°-176°c., is obtained when 1,2,3,11a-tetrahydro-5H-pyrrolo [2,1-c] [1,4] benzodiazepin-5,11(10H)-dione (prepared from proline and isatoic anhydride by the procedure of Example 1) is treated with 1M borane in tetrahydrofuran as described in the procedure of Example 1.

Sources & evidence

ORD record
ord-bc3067510c1f4da480bc051b0c111ab1
Source dataset
uspto-grants-1976_03
Patent number
US03947408

Reaction notes

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