4-Butylaniline → p-n-Butylanilino-7-methyl-1H-imidazo[4,5-f]quinoline Hydrochloride

Participants

Reaction Steps

A mixture of the compound of Example I, C. (21.7 g., 0.1 mole) and p-n-butylaniline (14.9 g., 0.1 mole) in ethanol (200 ml.) was stirred and refluxed overnight. The reaction solution was concentrated to dryness by rotary evaporator and the residue was collected and dried at 100°C to yield 36.5 g. (99.7%) yellow crystals, m.p. 296°-303°C. A small sample (5.0 g.) was recrystallized from nitromethane (750 ml.) and dried to yield 1.9 g. yellow crystals, m.p. 287°-302°C. A repeated recrystallization gave m.p. 303°-306°C.

Provenance & Evidence