Methanone, (4-methoxyphenyl)(2-phenyl-3-benzofuranyl)- → (4-Hydroxyphenyl)(2-phenyl-1-benzofuran-3-yl)methanone

HRID 268340Notes

Reaction equation

HRID 268340 reaction equation
C[O:2][C:3]1[CH:25]=[CH:24][C:6]([C:7]([C:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][C:10]=2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:8])=[CH:5][CH:4]=1.Cl.N1C=CC=CC=1>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([C:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][C:10]=2[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:8])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 6613416Methanone, (4-methoxyphenyl)(2-phenyl-3-benzofuranyl)-HCID 10176127Pyridinium chloride

Product 1

HCID 13264991(4-Hydroxyphenyl)(2-phenyl-1-benzofuran-3-yl)methanone

Procedure

3-(4-Methoxybenzoyl)-2-phenylbenzofuran (16.4 g., 0.05 mol.) is combined with 50 g. of freshly distilled pyridine hydrochloride and the mixture is refluxed 1 hour. The hot mixture is poured with stirring onto an ice-dilute hydrochloric acid mixture and the precipitate is collected to give 3-(4-hydroxybenzoyl)-2-phenylbenzofuran.

Workup

  1. additionThe hot mixture is poured
  2. customthe precipitate is collected

Sources & evidence

ORD record
ord-0ce6b454a8994fe0a6e9a8453c75f8a3
Source dataset
uspto-grants-1976_03
Patent number
US03947470

Reaction notes

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