HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Ethyl Ketone → 3-[4-(3-Di-n-butylaminopropoxy)benzoyl]-2-phenylbenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Ethyl Ketone | HCID 6569 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(3-Chloropropyl)dibutylamine | HCID 96084 | — |
| Reactant | (4-Hydroxyphenyl)(2-phenyl-1-benzofuran-3-yl)methanone | HCID 13264991 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-[4-(3-Di-n-butylaminopropoxy)benzoyl]-2-phenylbenzofuran | HCID 21435318 | — |
Reaction Steps
A mixture of 2.0 g. (6.4 mmol.) of 3-(4-hydroxybenzoyl)-2-phenylbenzofuran, 1.3 g. (6.4 mmol.) of 3-di-n-butylaminopropyl chloride and 4.0 g. (0.04 mol.) of anhydrous potassium carbonate in 20 ml. of dry 2-butanone is refluxed for 18 hours. The reaction is cooled, water and ether are added and the layers are separated. The organic phase is extracted with 10% aqueous sodium hydroxide and the aqueous layers are combined and extracted again with water. The combined ether extracts are concentrated under reduced pressure to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947470 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-53826219a097465b97c761cc54cc0b80 |
| Source note | uspto-grants-1976_03 |