Diethylamine → HCID 21435252, compound

HRID 268361Notes

Reaction equation

HRID 268361 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[C:7]([C:16](=[O:28])[C:17]3[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][CH2:26]Br)=[CH:19][CH:18]=3)[C:6]=2[CH:29]=1.[CH2:30]([NH:32][CH2:33][CH3:34])[CH3:31]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[C:7]([C:16](=[O:28])[C:17]3[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][CH2:26][N:32]([CH2:33][CH3:34])[CH2:30][CH3:31])=[CH:19][CH:18]=3)[C:6]=2[CH:29]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 214353905-Chloro-3-[4-(3-bromopropoxy)benzoyl]-2-phenylbenzofuran

Product 1

HCID 21435252HCID 21435252, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Chloro-3-[4-(3-bromopropoxy)benzoyl]-2-phenylbenzofuran (2.0 g., 4.3 mmol.) is refluxed in 100 ml. of ethanol containing 9 ml. of diethylamine for 10 hours. The reaction mixture is concentrated under reduced pressure and the residue is dissolved in ether. The ether solution is washed with aqueous sodium hydroxide and water then concentrated to give the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutionthe residue is dissolved in ether
  3. washThe ether solution is washed with aqueous sodium hydroxide and water
  4. concentrationthen concentrated

Sources & evidence

ORD record
ord-2d4419f613614b3dbcfc90f98be19c18
Source dataset
uspto-grants-1976_03
Patent number
US03947470

Reaction notes

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