Diethylamine → HCID 21435271, compound

HRID 268372Notes

Reaction equation

HRID 268372 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:28]=[CH:27][C:9]([C:10]([C:12]2[O:13][C:14]3[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=3[C:16]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:11])=[CH:8][CH:7]=1.[CH2:29]([NH:31][CH2:32][CH3:33])[CH3:30]>C(O)C>[CH2:29]([N:31]([CH2:32][CH3:33])[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:28]=[CH:27][C:9]([C:10]([C:12]2[O:13][C:14]3[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=3[C:16]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:11])=[CH:8][CH:7]=1)[CH3:30]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 21435288HCID 21435288, compound

Product 1

HCID 21435271HCID 21435271, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-[4-(3-Bromopropoxy)benzoyl]-3-phenylbenzofuran (2.5 g., 5.7 mmol.) is refluxed for 6 hours in 50 ml. of ethanol containing 20 ml. of diethylamine. The reaction mixture is concentrated under reduced pressure and the residue is dissolved in chloroform. The chloroform solution is washed with water, saturated aqueous sodium chloride solution and water, dried (MgSO4) and concentrated to give the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutionthe residue is dissolved in chloroform
  3. washThe chloroform solution is washed with water, saturated aqueous sodium chloride solution and water
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-1e0d99288e004a748b25236779e46fa2
Source dataset
uspto-grants-1976_03
Patent number
US03947470

Reaction notes

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