反应详情

1,1-Dibromo-2-(4-ethylphenyl)ethylene (1.1 g., 3.69 mmol.) is dissolved in 20 ml. of dry tetrahydrofuran and maintained under a nitrogen atmosphere. The solution is cooled to -78° and 3.9 ml. of a 1.9 M solution of butyl lithium in hexane is added with stirring. The reaction mixture is stirred 1 hour at -78°, then warmed to ambient temperature and stirred an additional hour. Water is added, the mixture is extracted with petroleum ether, the extracts are combined, dried (MgSO4) and concentrated to give 4-ethylphenylacetylene.

1. temperatureThe solution is cooled to -78°
2. stirringThe reaction mixture is stirred 1 hour at -78°
3. stirringstirred an additional hour
4. extractionthe mixture is extracted with petroleum ether
5. dry with materialdried (MgSO4)
6. concentrationconcentrated