Hydrochloric Acid → HCID 70167919, compound

HRID 268458Notes

Reaction equation

HRID 268458 reaction equation
C([NH:8][C:9](=[O:22])[CH2:10][NH:11][C:12](=[O:21])[C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1C(O)=O)C1C=CC=CC=1.[ClH:23].[H][H]>C(O)(=O)C.[Pd]>[ClH:23].[NH:14]1[CH2:15][CH2:16][CH2:17][C@H:13]1[C:12]([NH:11][CH2:10][C:9]([NH2:8])=[O:22])=[O:21]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 70584179HCID 70584179, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 70167919HCID 70167919, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 2-[(N-carboxy-L-prolyl)amino]acetamide N-benzyl ester (Ex. 9, 610 mg, 2 mmoles) in glacial acetic acid (8 ml) containing hydrogen chloride (2 mmoles) is agitated with palladium on charcoal (5%, 50 mg) in an atmosphere of hydrogen in the same manner as described in Example 6 until one molar equivalent of hydrogen has been consumed. Filtration, evaporation of the filtrate and drying of the residue under reduced pressure gives the title compound which is used as such in the subsequent step.

Workup

  1. customhas been consumed
  2. filtrationFiltration, evaporation of the filtrate
  3. customdrying of the residue under reduced pressure

Sources & evidence

ORD record
ord-8b5f0d9111a043f6962da6c0c914a16c
Source dataset
uspto-grants-1976_03
Patent number
US03947569

Reaction notes

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