Dimethylformamide dimethyl acetal → HCID 53830000, compound

HRID 268478Notes

Reaction equation

HRID 268478 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[C:6](=[O:17])[CH2:7][CH2:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.CO[CH:22](OC)[N:23]([CH3:25])[CH3:24]>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[C:6](=[O:17])[C:7](=[CH:22][N:23]([CH3:25])[CH3:24])[CH2:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 12948277HCID 12948277, compound

Product 1

HCID 53830000HCID 53830000, compound

Procedure

The mixture of 2.2 g of 8-chloro-1-phenyl-3,4-dihydro-2-benzazepin-5-one and 15 ml of dimethylformamide-dimethylacetal is refluxed for one hour and the excessive reagent removed under reduced pressure at a temperature not exceeding 135°. The residue is crystallized from diethyl ether, to yield the 8-chloro-4-dimethylaminomethylidene-1-phenyl-3,4-dihydro-2-benzazepin-5-one; m.p. 179°-180°.

Workup

  1. temperatureis refluxed for one hour
  2. customthe excessive reagent removed under reduced pressure at a temperature not
  3. customexceeding 135°
  4. customThe residue is crystallized from diethyl ether

Sources & evidence

ORD record
ord-d278fef9c6504e19b602798129c53e01
Source dataset
uspto-grants-1976_03
Patent number
US03947585

Reaction notes

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