Benzoyl isothiocyanate → N-benzoyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

HRID 26854Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[C:12]([N:20]=[C:21]=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:12]([NH:20][C:21]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 68284Benzoyl isothiocyanate

HCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 20557690N-benzoyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

Procedure

By the procedure of Example 46, N-(2-pyrimidylmethyl)ethylenediamine is reacted with benzoyl isothiocyanate to give N-benzoyl-N'-[2-(2-pyrimidylmethylamino)-ethyl]thiourea.

Sources & evidence

ORD record: ord-f21a0e9b237540928dfe5e322a80089a
Source dataset: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04151288

Reaction notes

Loading…