Hydrazine hydrate (1:1) → HCID 21551879, compound

HRID 268542Notes

Reaction equation

HRID 268542 reaction equation
[F:1][C:2]([F:48])([F:47])[C:3]1[CH:4]=[CH:5][C:6]([N:18]2[C:22]([CH2:23][N:24]3C(=O)C4=CC=CC=C4C3=O)=[N:21][N:20]=[C:19]2[CH2:35][N:36]2C(=O)C3=CC=CC=C3C2=O)=[C:7]([CH:17]=1)[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16])=O.O.NN>C(O)C>[F:1][C:2]([F:47])([F:48])[C:3]1[CH:4]=[CH:5][C:6]2[N:18]3[C:19]([CH2:35][NH2:36])=[N:20][N:21]=[C:22]3[CH2:23][N:24]=[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[Cl:16])[C:7]=2[CH:17]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21551900HCID 21551900, compound

Product 1

HCID 21551879HCID 21551879, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 22, 5-trifluoromethyl-2'-chloro-2-[3,5-bis(phthalimidomethyl)-4H-1,2,4-triazol4-yl]benzophenone in ethanol is heated with hydrazine hydrate to give 8-trifluoromethyl-1-(aminomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-aa27cbe44f4b4e19bd6ea48ec4b82441
Source dataset
uspto-grants-1976_03
Patent number
US03947466

Reaction notes

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