Hydrazine hydrate (1:1) → HCID 21551914, compound

HRID 268546Notes

Reaction equation

HRID 268546 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:17]2[C:21]([CH2:22][N:23]3C(=O)C4=CC=CC=C4C3=O)=[N:20][N:19]=[C:18]2[CH2:34][N:35]2C(=O)C3=CC=CC=C3C2=O)=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15])=O.O.NN>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:17]3[C:18]([CH2:34][NH2:35])=[N:19][N:20]=[C:21]3[CH2:22][N:23]=[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[F:15])[C:6]=2[CH:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21551901HCID 21551901, compound

Product 1

HCID 21551914HCID 21551914, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 22, 5-bromo-2'-fluoro-2-[3,5-bis(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is heated with hydrazine hydrate to give 8-bromo-1-(aminomethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-3721ba7c9ee2459fb54a7000da1fae2e
Source dataset
uspto-grants-1976_03
Patent number
US03947466

Reaction notes

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