Hydrazine hydrate (1:1) → HCID 20406679, compound

HRID 268548Notes

Reaction equation

HRID 268548 reaction equation
[C:1]1(=O)[N:5]([CH2:6][C:7]2[N:11]([C:12]3[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=3C(C3C=CC=CC=3)=O)[C:10]([CH2:26][N:27]3C(=O)C4=CC=CC=C4C3=O)=[N:9][N:8]=2)C(=O)[C:3]2=[CH:39][CH:40]=[CH:41][CH:42]=[C:2]12.O.NN>C(O)C>[NH2:27][CH2:26][C:10]1[N:11]2[C:12]3[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=3[C:1]([C:2]3[CH:3]=[CH:39][CH:40]=[CH:41][CH:42]=3)=[N:5][CH2:6][C:7]2=[N:8][N:9]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21551905HCID 21551905, compound

Product 1

HCID 20406679HCID 20406679, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 22, 2-[3,5-bis(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is heated with hydrazine hydrate to give 1-(aminomethyl)6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-0cf6cd8eb28f404b883368e2d0353e36
Source dataset
uspto-grants-1976_03
Patent number
US03947466

Reaction notes

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