4-(Trifluoromethyl)phenyl isocyanate → HCID 10183288, compound

HRID 268615Notes

Reaction equation

HRID 268615 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]=[O:11])=[CH:5][CH:4]=1.[NH2:14][CH:15]([CH:31]([CH3:33])[CH3:32])[C:16]([N:18]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])=[O:17]>>[CH2:24]([N:18]([CH2:19][CH2:20][N:21]([CH3:22])[CH3:23])[C:16](=[O:17])[C@@H:15]([NH:14][C:10]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:12])([F:13])[F:1])=[CH:8][CH:7]=1)=[O:11])[CH:31]([CH3:32])[CH3:33])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 737684-(Trifluoromethyl)phenyl isocyanateHCID 21938687HCID 21938687, compound

Product 1

HCID 10183288HCID 10183288, compound

Procedure

Compound 14c was prepared from 4-(trifluoromethyl)phenyl isocyanate and compound 13, using the method described in Example 22. MS (EI)=464 (M+).

Sources & evidence

ORD record
ord-d0e4df3f36bd4c12ad5c2212390953c5
Source dataset
uspto-grants-2008_11
Patent number
US07446115B2

Reaction notes

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