2-Fluoro-4-biphenylboronic Acid → 2-[1-Ethyl-8-(2-fluoro-biphenyl-4-YL)-6-isopropyl-1,3,4,9-tetrahydro-pyrano[3,4-B]indol-1-YL]-ethanol
Reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:20]([CH3:22])[CH3:21])[CH:5]=[C:6]2[C:10]=1[NH:9][C:8]1[C:11]([CH2:17][CH2:18][OH:19])([CH2:15][CH3:16])[O:12][CH2:13][CH2:14][C:7]2=1.[F:23][C:24]1[CH:29]=[C:28](B(O)O)[CH:27]=[CH:26][C:25]=1[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH2:15]([C:11]1([CH2:17][CH2:18][OH:19])[C:8]2[NH:9][C:10]3[C:6]([C:7]=2[CH2:14][CH2:13][O:12]1)=[CH:5][C:4]([CH:20]([CH3:22])[CH3:21])=[CH:3][C:2]=3[C:28]1[CH:27]=[CH:26][C:25]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[C:24]([F:23])[CH:29]=1)[CH3:16]Participants
3
Procedure
The title compound is prepared in a manner analogous to Example 1, except using 2-(8-bromo-1-ethyl-6-isopropyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-ethanol and 2-fluorobiphenyl-4-boronic acid in step 1.F.
Sources & evidence
- ORD record
- ord-9a035ebbe7cf4894a882316a581b9c67
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07446122B2
Reaction notes
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