HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268671Generated: October 29, 2026
Hydrochloric Acid → 2-(Hydroxyimino)-N-[2-(propan-2-yl)phenyl]acetamide
https://huagongshe.com/reaction/268671
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Chloral Hydrate | HCID 2707 | — |
| Reactant | 2-Isopropylaniline | HCID 12561 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(Hydroxyimino)-N-[2-(propan-2-yl)phenyl]acetamide | HCID 71443947 | 60.4% |
Reaction Steps
A mixture of 2-isopropylaniline (4.7 g, 35 mmol), Na2SO4 (30.0 g), concentrated hydrochloride (3 mL), chloral hydrate (6.5 g), hydroxylamine hydrochloride (8.00 g) in water (150 mL) was heated at 85° C. for 40 minutes. After cooling to room temperature, it was extracted with ethyl acetate. The extracts were dried over magnesium sulfate and evaporated to dryness. Flash chromatography on silica gel provided 4.357 g (54%) of the title compound as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07446122B2 |
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| Source dataset | uspto-grants-2008_11 |
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| ORD ID | ord-22098764123d48c78493090e0fd8f717 |
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| Source note | uspto-grants-2008_11 |
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