反应详情

温度

85 °C

A mixture of 2-isopropylaniline (4.7 g, 35 mmol), Na2SO4 (30.0 g), concentrated hydrochloride (3 mL), chloral hydrate (6.5 g), hydroxylamine hydrochloride (8.00 g) in water (150 mL) was heated at 85° C. for 40 minutes. After cooling to room temperature, it was extracted with ethyl acetate. The extracts were dried over magnesium sulfate and evaporated to dryness. Flash chromatography on silica gel provided 4.357 g (54%) of the title compound as solid.

1. temperatureAfter cooling to room temperature
2. extractionit was extracted with ethyl acetate
3. dry with materialThe extracts were dried over magnesium sulfate
4. customevaporated to dryness