反应详情

To a stirred solution of tert-butyl 7-hydroxychromane-3-carboxylate (250 mg, 1 mmol) in CH3CN (10 ml), K2CO3 (414 mg) and 3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl methanesulfonate (325 mg) were added and the reaction mixture was heated under reflux for overnight. The reaction mixture was cooled to room temperature and diluted with 30 mL of diethyl ether. The diluted solution was passed through a pad of silica and the silica was washed with more ether. The ether solution was evaporated to dryness and purified using silica chromatography. The product was isolated as a white sold (397 mg, 88%).

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux for overnight
3. washthe silica was washed with more ether
4. customThe ether solution was evaporated to dryness
5. custompurified
6. customThe product was isolated as