反应详情

A solution of ethyl 4-(3-piperidin-1-ylpropoxy)benzoate (D1) (82.57 g) in concentrated hydrochloric acid (750 ml) was heated under reflux for 2 h. The mixture was cooled to rt then chilled to 5° C. and filtered. The filter cake was washed with acetone and dried to yield the title compound (D2) as a white crystalline solid (75.30 g) that displayed MS and 1H NMR spectra that were identical to those of the product obtained by D2 (Method A).

1. temperatureunder reflux for 2 h
2. temperaturethen chilled to 5° C.
3. filtrationfiltered
4. washThe filter cake was washed with acetone
5. customdried