反应详情

4-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride (D2) (0.23 g) in thionyl chloride (5 ml) was heated under reflux for 1 h. The reaction mixture was then evaporated to a minimum and co-evaporated from DCM (3×10 ml) to give the title compound (D3) as a white powder (0.24 g).

1. temperatureunder reflux for 1 h
2. customThe reaction mixture was then evaporated to a minimum