HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride → 4-(3-Piperidin-1-ylpropoxy)benzoyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride | HCID 68963614 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | 4-(3-Piperidin-1-ylpropoxy)benzoyl chloride hydrochloride | HCID 21852062 | 196.6% |
Reaction Steps
4-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride (D2) (0.23 g) in thionyl chloride (5 ml) was heated under reflux for 1 h. The reaction mixture was then evaporated to a minimum and co-evaporated from DCM (3×10 ml) to give the title compound (D3) as a white powder (0.24 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446103B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-67c8ebd31205405786cdabfc6fd90b85 |
| Source note | uspto-grants-2008_11 |