HCID 68968162, compound → HCID 17986293, compound

HRID 268723Notes

Reaction equation

HRID 268723 reaction equation
[ClH:1].[Cl:2][C:3]1[CH:11]=[C:10]([O:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6]>S(Cl)(Cl)=O>[ClH:2].[Cl:2][C:3]1[CH:11]=[C:10]([O:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:9]=[CH:8][C:4]=1[C:5]([Cl:1])=[O:6]

Participants

3

Reactant 1

HCID 68968162HCID 68968162, compound

Product 1

HCID 17986293HCID 17986293, compoundYield 189.5%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

2-Chloro-4-(3-piperidin-1-ylpropoxy)benzoic acid hydrochloride (D27) (1.0 g) was heated at reflux in thionyl chloride (20 ml) for 1.5 h. The thionyl chloride was removed by evaporation and the residue evaporated from DCM (3×30 ml) to give the title compound (D28) (1.0 g).

Workup

  1. customThe thionyl chloride was removed by evaporation
  2. customthe residue evaporated from DCM (3×30 ml)

Sources & evidence

ORD record
ord-1656746903af49b4ba3c6862b0fb1892
Source dataset
uspto-grants-2008_11
Patent number
US07446103B2

Reaction notes

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