Hydrochloric Acid → 2-Chloro-4-(piperidin-4-yloxy)-benzonitrile hydrochloride

HRID 268724Notes

Reaction equation

HRID 268724 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 17986305HCID 17986305, compound

Product 1

HCID 179862902-Chloro-4-(piperidin-4-yloxy)-benzonitrile hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Chloro-4-[(1-tert-butoxycarbonyl-4-piperidinyl)oxy]benzonitrile (D29) (5.0 g) was dissolved in methanol (150 ml) and 4N HCl in dioxane (100 ml) was added. The reaction stirred at rt overnight. The reaction mixture was then evaporated to give the title compound (D30) as a white solid (4.0 g).

Workup

  1. customThe reaction mixture was then evaporated

Sources & evidence

ORD record
ord-5f60f505214a4d989575c79bb5cceb03
Source dataset
uspto-grants-2008_11
Patent number
US07446103B2

Reaction notes

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